In a feature published by goop, Dr. Babak Azizzadeh offers expert insight on the science behind the brand’s latest skincare launch: the Youth-Boost NAD+ Peptide Rich Cream, hailed by Gwyneth Paltrow as her new “holy grail” moisturizer.
The article explores the growing interest in NAD+, a molecule long associated with longevity medicine for its role in cellular energy production, DNA repair, and aging pathways. While NAD+ has traditionally been used in supplements and IV therapies, researchers are now exploring how its precursors can be effectively delivered through topical skincare to support skin health and resilience.
Dr. Azizzadeh highlights niacinamide, one of the most extensively researched NAD+ precursors, as a key ingredient in goop’s Youth-Boost line. Rather than attempting to stabilize pure NAD+—which is notoriously difficult in topical formulations—the product uses advanced precursors such as NMN to help support the skin’s natural NAD+ production pathways.
Reviewing the formulation, Dr. Azizzadeh emphasizes the importance of a multi-layered approach to aging skin, particularly as the epidermal barrier becomes thinner, drier, and more reactive over time. He notes that the inclusion of postbiotics, ceramides, peptides, and plant-based retinol alternatives helps stabilize the skin barrier, reduce inflammation, and improve tolerance—allowing performance-driven actives to deliver results without irritation.
The article also cites clinical and consumer studies showing significant improvements in hydration, firmness, texture, and visible lines after consistent use, reinforcing the cream’s positioning as both a luxury and science-forward skincare innovation.
👉 Read the full article on goop.com:
Gwyneth Has a New “Holy Grail” Moisturizer—and You’re Definitely Going to Want to Try It